現(xiàn)貨moradec AH-107-DX說明書

αHFc-CL-DX8951

抗人IgG Fc-DX8951抗體與可裂解連接子

目錄號(hào)：AH-107-DX

αHFc-CL-DX8951是一種抗人IgG Fc特異性抗體，與甲磺酸埃克替康（DX8951）結(jié)合。抗體部分是對(duì)人IgG的Fc區(qū)特異的多克隆抗體。甲磺酸埃克替康（DX8951）是一種拓?fù)洚悩?gòu)酶I抑制劑。連接DX8951和抗體的可裂解接頭（GGFG）在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過內(nèi)吞作用進(jìn)入細(xì)胞，則在內(nèi)體中被裂解。

αHFc-CL-DX8951

Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker	Catalog Number: AH-107-DX
αHFc-CL-DX8951 is anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.